In adults, the normal kidney is 10-14 cm long in males and 9-13 cm long in females, 3-5 cm wide, 3 cm in antero-posterior thickness and weighs 150-260 g. The left kidney is usually slightly larger than the right. The renal corpuscle has two components: the glomerular (Bowmans) capsule in which sits the glomerulus. The solid renal parenchyma consists of the peripheral renal cortex and more central renal medulla. Crossed ectopia on intravenous pyelogram. IVC, Inferior vena cava. A, Enhancement of the mass is conspicuous in the corticomedullary phase. Thus, an AML is a tumor that contains these 3 components. I would honestly say that Kenhub cut my study time in half. AMLs can bleed and while not cancerous are still taken very seriously. The kidneys are innervated by the renal plexus. Although each kidney is about the size of a fist, the approximately one million nephrons per kidney require nearly 20% of the total cardiac output to perform this multitude of functions. A simple calyx receives urine from a single papilla; a compound calyx receives urine from multiple papillae (Fig. print Print this Article Approximately 1 year before presentation, the patient experienced a similar episode of right flank pain that prompted an unenhanced CT examination of the abdomen and pelvis at an outside institution. Kidneys are located just below your ribcage and behind your belly. Each kidney should always be evaluated in long axis (coronal, sagittal, or both, depending on sonographic window) and axial to the kidney. The kidneys have two functional areas that are managed and staged independently, the kidney parenchyma and the renal pelvis. Table 18-7 Causes of Unilateral Small Smooth Kidney, Only gold members can continue reading. Renal size and cortical thickness can be assessed in a manner similar to ultrasound. The MDRD calculation is more complicated than calculating creatinine clearance (taking into account body surface area, sex, and race) but is thought to be more accurate than estimated creatinine clearance, particularly among the elderly and obese. 18-25). However, small, low-attenuation lesions in the medulla are often obscured during this phase. Unilateral renal agenesis occurs in approximately 1 in 1000 individuals with minimal impact on health, although it is sometimes associated with other congenital anomalies of the genitourinary tract and musculoskeletal system. Ultrasound can often identify the cause in cases of bilateral obstruction (Fig. Coronal computed tomographic image in the corticomedullary phase shows normal corticomedullary differentiation along the lobulated contour, consistent with fetal lobulation. This is called the nutcracker phenomenon. Figure 18-23 Axial image of the left kidney obtained in the excretory phase of a computed tomographic urogram demonstrates the effects of window settings on visualizing structures near excreted contrast. Sometimes, one or both kidneys fail to develop, which causes unilateral or bilateral renal agenesis. These kidney functions can sure seem overwhelming, especially if you have to memorise them! 18-3). Figure 18-19 Sagittal ultrasound image of the right kidney demonstrates increased size and echogenicity of the kidney, findings typical of human immunodeficiency virus nephropathy. The kidneys are positioned retroperitoneally, meaning that they are not wrapped with the peritoneal layers the way most abdominal organs are, but rather are placed behind it. Poorly functioning kidneys with little residual parenchymal volume may be removed because preservation offers opportunities for future complications (infection, hypertension) without contributing significantly to renal function. Since the abdominal organs are not paired, the left kidney is not related to the same organs as the right kidney. Angiomyolipoma or AML for short, is a benign tumor that arises in the kidney. The ureter and calyces were not dilated (not shown), helping to differentiate this anatomic variant from obstruction. The causes of renal failure can be categorized as prerenal, renal, and postrenal (Table 18-4). Note that there is no contrast in the aorta. Pitfall: An extrarenal pelvis may be mistaken for hydronephrosis. The defect proved to be blood clot from papillary necrosis. Dimitrios Mytilinaios MD, PhD Further testing/diagnosis is required. Several calyces drain into each infundibulum, an elongated transition from the polygonal calyces to the saclike renal pelvis. This is because the liver and the stomach offset the symmetry of the abdomen, with the liver forcing the right kidney a bit down, and the stomach forcing the left kidney a bit up. 18-2). Advantages of scintigraphy include accurate quantitative measurement of function and parenchymal mass without the risks for nephrotoxicity associated with iodinated contrast media or nephrogenic systemic fibrosis associated with gadolinium contrast agents. Other methods include classical surgical removal of the stone, either through the ureter or by open surgery. Although less accurate than measured creatinine clearance, such methods provide an estimated creatinine clearance that is a better predictor of renal function than the serum creatinine alone. The anteromedial aspect of the interpolar region is interrupted by the renal hilum to make a C shape. Concerning lymphatic drainage, each kidney drains into the lateral aortic (lumbar) lymph nodes, which are placed around the origin of the renal artery. Kidney cysts are round pouches of fluid that form on or in the kidneys. Although ureteral contrast media is typically present before 3 minutes, longer delays provide more predictable opacification. Note that there is no contrast in the aorta. The axes of the renal moeities are abnormal with the inferior poles angled medially. A, Tips of the fornices are sharply defined. Hydronephrosis is important to detect, because obstructive uropathy is often reversible if identified early. Literature supports the use of either multidetector computed tomography (MDCT) or MRI in donor evaluation. The Modification of Diet in Renal Disease (MDRD) is another method for estimating renal function that yields a value often called estimated glomerular filtration rate (eGFR). Besides blood volume and pressure regulation, kidneys also participate in the production of calcitriol (the active form of vitamin D). Renal artery a bifid renal pelvis, ultimately drained by a common ureter. Because the interlobular arteries form an arch overlying the pyramid, they are called the. Some of them are congenital, such as a third kidney, which is usually atrophic. Due to the segmental vascular supply of the kidney it is often feasible to ligate the relative arteries and veins and remove the tumour with a safe zone of healthy surrounding parenchyma ( partial nephrectomy) without removing the entire kidney or compromising its total vascular supply by ischaemia. Normal magnetic resonance imaging appearance of the kidneys. 18-15). Reviewer: Checklist Approach to Ultrasound for Renal Failure, Absence of hydronephrosis makes postrenal causes unlikely, Cortical atrophy in one or both kidneys: suspect chronic or acute-on-chronic renal failure, Increased cortical echogenicity is associated with many forms of chronic renal parenchymal disease and indicates a renal cause for renal failure. The urinary system comprises the upper urinary tracts (kidneys and ureters), the urinary bladder, and the urethra. Lets start with the right kidney anterior surface. Table 18-6 Causes of Bilateral Small Smooth Kidneys. Last reviewed: December 28, 2022 The region where the renal pelvis joins the ureter is called the ureteropelvic junction (UPJ). Extraaortic origin of the renal arteries and accessory renal arteries are common. and parenchymal mass without the risks for nephrotoxicity associated with iodinated contrast media or nephrogenic systemic fibrosis associated with gadolinium contrast agents. Supernumerary kidneys are quite rare and have been associated with aortic coarctation, vaginal atresia, and urethral duplications. Anterior components of circumaortic vein can be small. In this region, the anterior and posterior hilar lip is identified (Fig. Even when there is another plausible explanation for decreased renal function (e.g., known prerenal causes), ultrasound offers the opportunity to rapidly and noninvasively identify a potentially correctible cause of renal failure. and grab your free ultimate anatomy study guide! Each segmental branch of the renal artery divides into multiple interlobar arteries that course along the periphery of the medullary pyramids and causes small interlobular branches (Fig. When the renal arteries enter the kidney through the hilum, they split into anterior and posterior branches. When abnormal echogenicity is detected, it is important to note whether it is unilateral or bilateral. Cells in our body constantly produce hydrogen ions. When the fine, weblike complex of ureteral arteries is recruited to contribute to collateral circulation, enlarged vessels are seen surrounding the proximal ureter, causing the classic ureteral notching seen on intravenous urogram (IVU). Since they are located deep retroperitoneally, the easiest way to examine them is from the patients back. The segmental arteries then branch into the interlobar arteries, which further branch into the arcuate arteries. Figure 18-7 Axial image of the left kidney from a contrast-enhanced computed tomographic scan demonstrates an extrarenal pelvis. Urine that is concentrated in the renal papilla is subsequently excreted into a lumen lined with transitional epithelium. Urine that is concentrated in the renal papilla is subsequently excreted into a lumen lined with transitional epithelium. They are staged the same way as the renal pelvis. Anatomy Where is the renal cortex? The parenchyma of the kidney consists of the outer renal cortex, and inner renal medulla. Calculation of the estimated renal volume is considered by some to be the most accurate assessment of renal size available with ultrasound, although renal length alone is more commonly reported. "Angio" indicates blood vessels, "myo" indicates muscle, and "lipoma" indicates fat. Figure 18-17 Coronal maximum intensity projection image from a contrast-enhanced computed tomographic scan demonstrates a dilated and tortuous lumbar veins joining the left renal vein. As the lobules of metanephric blastema coalesce to form each kidney, they do not always result in a smooth, uniform band of cortex. Renal size can be measured in several ways. Unenhanced MRI can also be used to diagnose obstruction and identify the source (Fig. If this appearance were present bilaterally, chronic renal disease such as chronic glomerulonephritis would be a more likely explanation. Unenhanced CT can identify hydronephrosis and hydroureter, urinary stones, and some masses. This phenomenon is due to T2-shortening and susceptibility (T2*) effects caused by concentrated gadolinium, and can potentially obscure filling defects and urothelial lesions. It is important to note, however, that the appearance of hydronephrosis does not necessarily indicate urinary obstruction (see Hydronephrosis and Its Mimics section later in this chapter). Hypotension is a stimulus for the kidneys to increase the retention of fluid and thus increase blood pressure. Imaging must provide detailed images of the renal parenchyma and a survey of arterial, venous, and ureteral anatomy. Learning anatomy is a massive undertaking, and we're here to help you pass with flying colours. A potential benefit of MRI is the lack of exposure to ionizing radiation, although unenhanced CT would still be required to detect stones (the presence of stones increases the donors risk for renal insufficiency later in life and could disqualify them as a donor candidate). During the 6th to 9th weeks of life, the kidneys begin to ascend from their position in the pelvis to the level of T12-L1, inferior to the adrenal glands. Conventional surgery for congenital UPJ obstruction involves an open pyeloplasty, in which some tissue is removed from the wall of the saclike renal pelvis to form a more tapered, efficient, funnel-shaped renal pelvis. 18-18). Use of MR contrast agents in renal failure poses a lower risk than iodinated contrast material for exacerbating renal failure, but there is evidence that gadolinium-based MR contrast media pose some risk for systemic complications (nephrogenic systemic fibrosis) and should be used with caution in patients with severe or acute renal insufficiency. The calyces, however, will have a normal appearance with an unobstructed extrarenal pelvis but will be dilated in cases of urinary obstruction. MR angiography can be useful for the diagnosis of renal vascular abnormalities. Because production of creatinine is affected by sex, age, muscle mass, protein intake, and liver function, the serum creatinine can be an inaccurate predictor of renal function, particularly in those at the extremes of age and body weight. Computed Tomographic Evaluation for Renal Failure, Magnetic Resonance Evaluation for Renal Failure. This layer sits posteriorly and posterolaterally to each kidney and separates it from the muscles of the abdominal wall. When hydronephrosis is absent, the causative factor for acute renal failure is almost certainly prerenal or renal. The kidneys are paired retroperitoneal structures that are normally located between the transverse processes of T12-L3 vertebrae, with the left kidney typically somewhat more superior in position than the right. A, A low-attenuation lesion is difficult to identify during the corticomedullary phase. Frequent urination (having to go the bathroom often). Association between Renal Cortical Echogenicity and Renal Parenchymal Disease. Each pyramid creates urine and terminates into a renal papilla. Look for retroaortic or circumaortic left renal vein. Retrograde urogram shows a calculus in the left ureter. Chronic glomerulonephritis usually causes bilateral increased renal echogenicity with smooth atrophy, whereas renal artery stenosis usually causes a similar but unilateral appearance (Fig. But more often, kidney cysts are a type called simple kidney cysts. Kidney cysts can occur with disorders that may impair kidney function. Table 18-7 lists causes of unilateral smooth renal atrophy. Fetal lobulation is best differentiated from renal scars during the corticomedullary phase of enhancement on computed tomography (CT) or magnetic resonance imaging (MRI) because cortex can be followed into the indentation that occurs between calyces (Fig. Identify abnormal course of main or accessory right renal artery anterior rather than posterior to inferior vena cava (Fig. 3D printed model for a 53-year-old female presenting a 21 15 15 mm renal tumor located in the interpolar region of left kidney, treated by left partial nephrectomy. Figure 18-15 Relation between the right renal artery and the inferior vena cava (IVC). In fact, evaluation of the renal collecting system during the excretory phase often requires window and level settings approaching those used for evaluating the osseous structures (Fig. Prominent extrarenal pelves are typically positioned anteriorly (Fig. The most common cause is renal artery stenosis (see Fig. Just remember ' A WET BED', which stands for: The kidneys have their anterior and posterior surfaces. A. Junctional cortical line seen on a long-axis ultrasound image of the right kidney. The left kidney (not shown) had a similar appearance. * Entities for which sonography is most useful. Kenhub. Each time a professor says 'nephron', a student gets a headache. Some centers use diuretics or fluid bolus, or both, during CT urography to dilute the excreted contrast to improve assessment of the urothelium. The small portion of the lumen surrounding the papilla is called the calyx. The presence or absence of intravenous contrast media, as well as the phase of contrast enhancement, are key factors that determine the appearance of the renal parenchyma on CT (Table 18-3). 18-26). The vascularity of some tumors may be most apparent during this phase (Fig. more lateral and anterior than the superior poles. This causes them to fire impulses which stimulate rhythmical contraction and relaxation, called peristalsis. Some forms of congenital UPJ obstruction are now treated with transureteroscopic endopyelotomy in which an incision is made from within the ureter using a ureteroscope. Renal size can be measured in several ways. The glomerular membrane is designed in a way in which it is not permeable for big and important molecules in blood, such as plasma proteins, but it is permeable to the smaller substances such as sodium, potassium, amino acids and many others. Of course, if the situation is the other way around (less than 5 liters of blood), blood pressure is too low (hypotension). They extend from lumbar vertebra T12-L3. Unlike the excretory phase of enhanced CT, signal intensity within the renal collecting systems is reduced on T1- and T2-weighted MR images once excreted gadolinium-based contrast media becomes sufficiently concentrated. Figure 18-1 Annotated three-dimensional volume rendering of the left kidney acquired using a combined nephrographic phase and excretory phase during computed tomographic urography demonstrates regional anatomy of the kidney. IVC, Inferior vena cava. Calculation of the estimated renal volume is considered by some to be the most accurate assessment of renal size available with ultrasound, although renal length alone is more commonly reported. The opposite situation is possible too, if the kidneys excrete too many hydrogen ions, the pH of blood becomes too alkaline, and leads to a state called alkalosis. Renal scintigraphy can be performed with a variety of agents to provide assessment of either function or structure of the kidneys. After looking at the overview of the kidneys in situ, it may seemas they are cluttered with all abdominal organs. Entities for which sonography is most useful. Fever. Box 18-2 provides some tips regarding crossing vessels in UPJ obstruction. In cases of unilateral obstruction with acute renal failure, sonographic evaluation may show evidence of chronic renal parenchymal disease in the unobstructed kidney. Serum creatinine, however, is dependent not only on its disposal but also its production. The kidney is a very important organ in regards to body homeostasis. In most cases, the kidneys are situated with the inferior poles slightly more lateral and anterior than the superior poles. Frontal image of the left kidney from an intravenous urogram demonstrating an aberrant renal papilla in the lower pole infundibulum. This specific condition is called the nutcracker phenomenon. The portion of the kidney between the poles is called the interpolar region and contains the renal hilum (Fig. Ultrasound performed for acute renal failure demonstrates bilateral hydronephrosis caused by a bladder tumor. 18-1). In adults, the normal kidney is 10-14 cm long in males and 9-13 cm long in females, 3-5 cm wide, 3 cm in antero-posterior thickness and weighs 150-260 g. The left kidney is usually slightly larger than the right. The upper pelvis is the most common ectopic location for the kidney; most cases are also associated with abnormalities of rotation. Most radiologists consider 10 to 12 cm to be an approximate reference range for renal length in adults, allowing for an additional 1 cm in either direction for patients at the extremes of height. February 12, 2018 - 2:17pm Pancake kidney describes a more severe fusion anomaly with a single, flat kidney positioned low in the pelvis with an anterior collecting system drained by either one or two ureters. C, More severe hydronephrosis results in more pronounced shortening of the papilla. On the other hand, babies with bilateral agenesis cannot survive without an immediate kidney transplant. There are 8-18 renal pyramids in each kidney, that on the coronal section look like triangles lined next to each other with their bases directed toward the cortex and apex to the hilum. Around 40% of kidney cancers are localized renal masses. Eliminating toxic metabolites through urine, regulation of blood homeostasis and blood pressure, production of some hormones, Positioned retroperitoneally, consists of the cortex and medulla, empties urine into the ureter (which carries urine to the urinary bladder), Renal artery (branch of the abdominal aorta), Renal vein (drains to the inferior vena cava), Third kidney, horseshoe kidney, kidney agenesis, kidney stones, acute kidney failure, Regulates the amount of fluid in the body by increasing or decreasing the urine production, Maintain the pH of blood at 7.4 by decreasing or increasing the excretion of hydrogen ions, Medial part of the lower half of superior pole, Lateral part of the lower half of superior pole, Lateral part of inferior half of anterior surface, Medial part of inferior half of anterior surface, The perinephric fat (perirenal fat capsule). Axial maximum intensity projection image from the arterial phase of a contrast-enhanced computed tomographic scan from a prospective renal donor demonstrates early prehilar branching of the left renal artery. Chronic obstruction, however, results in damage to the papilla, evident in the clubbed calyx of papillary necrosis (Fig. The presence of significant renal parenchyma may justify surgical repair to maximize the functional contribution of that kidney. If this appearance were present bilaterally, chronic renal disease such as chronic glomerulonephritis would be a more likely explanation. CT is occasionally used to evaluate patients with renal failure. A frontal section through the kidney reveals an outer region called the renal cortex and an inner region called the medulla. Living renal donor allografts account for more than half of the transplanted kidneys in the United States. Each end of the kidney is commonly called a pole. Perhaps of even greater importance, serum creatinine is not a sensitive test for minor insults to the kidney in otherwise healthy individuals. Supernumerary kidneys are quite rare and have been associated with aortic coarctation, vaginal atresia, and urethral duplications. RENAL ANATOMY Renal Parenchyma The kidneys can be divided into three main regions from cranial to caudal. urinary system quizzes and labeled diagrams. The anteromedial, aspect of the interpolar region is interrupted by the renal hilum to make a C shape. When multiple clefts in the renal cortex are present throughout the kidney, it is described as fetal lobulation. In other cases, each renal unit has its own ureter. Horseshoe kidneys result from midline fusion of the kidneys, typically at the level of the origin of the inferior mesenteric artery. Poorly functioning kidneys with little residual parenchymal volume may be removed because preservation offers opportunities for future complications (infection, hypertension) without contributing significantly to renal function. B, Low-attenuation lesion in the late nephrographic/early excretory phase is less suspicious in appearance. When abnormal echogenicity is detected, it is important to note whether it is unilateral or bilateral. As the lobules of metanephric blastema coalesce to form each kidney, they do not always result in a smooth, uniform band of cortex. In this region, the anterior and posterior. The kidneys are bilateral organs placed retroperitoneally in the upper left and right abdominal quadrants and are part of the urinary system. In some cases, two separate kidneys drain into a bifid renal pelvis, ultimately drained by a common ureter. Right-sided pain was related to crossed renal ectopia. If the renal pelvis is entirely within the confines of the renal sinus, it is considered intrarenal. The main function of the kidney is to eliminate excess bodily fluid, salts and byproducts of metabolism this makes kidneys key in the regulation of acid-base balance, blood pressure, and many other homeostatic parameters. Blood in the urine, or dark urine. The normal appearance of the calyx is created by the impression of the renal papilla. The renal pelvis then tapers like a funnel to join the ureter. In most cases, the kidneys are situated with the inferior poles slightly. The patient had right flank pain but had a solitary calcification in the left pelvis on plain radiograph (not shown). Table 18-6 lists the most common causes of bilateral smooth renal atrophy. In addition to the renal artery, accessory renal arteries are present too. Summary: A variety of factors, including patient body habitus, local renal anatomy, cost and patient preference, must be taken into consideration when determining the optimal treatment modality for lower pole renal calculi. It doesn't have to be that way. These terminal branches have no collateral circulation. Thoracic kidneys are the least common form of renal ectopia. Other common kidney conditions are acquired through life, and one of the most common is nephrolithiasis (kidney stones). The renal veins empty to the inferior vena cava, so the right vein is shorter because the inferior vena cava runs closer to the right kidney. Many clinical laboratories now provide computer-generated calculations of estimated creatinine clearance or eGFR using patient data in the medical information system. The kidneys are bilateral organs placed retroperitoneally in the upper left and right abdominal quadrants and are part of the urinary system. Renal Cysts. The kidney tissue is protected by three layers that entirely surround the kidney: Outside the fascia is the most superficial layer a layer of fat tissue called the paranephric fat. The upper pelvis is the most common ectopic location for the kidney; most cases are also associated with abnormalities of rotation. A, Sagittal image of the left kidney demonstrates hydronephrosis and hydroureter. Log In or, Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on Google+ (Opens in new window), Estimated Creatinine Clearance and Glomerular Filtration Rate, Cockroft and Gault Equation for Calculating Estimated Creatinine Clearance, The Modification of Diet in Renal Disease (MDRD) is another method for estimating renal function that yields a value often called, The kidneys can be divided into three main regions from cranial to caudal. Sagittal ultrasound image of the left kidney demonstrates a unilateral small, smooth, echogenic kidney in a patient with renal artery stenosis. For most of the students, the nephron is a mystical complexed structure that may be hard to understand. Yet, the relations of the kidneys with other organs are often found in Anatomy tests. So the pyramids represent the functional tissue that creates urine, whereas the calyces are the beginning of the ureter and transport the urine to it. Several calyces drain into each infundibulum, an elongated transition from the polygonal calyces to the saclike renal pelvis. Ultrasound It can be seen as a triangular echogenic cortical defect, frequently seen in upper lobe parenchyma. Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster. In clinical practice, it is probably best to categorize the renal cortex as hypoechoic, isoechoic, or hyperechoic compared with normal liver, and then state a correlative risk for associated renal parenchymal disease (Table 18-2). When echogenicity of the renal cortex equals that of the liver, renal function is abnormal in approximately 38% of cases. aware of such a vessel, the urologist may choose to perform an alternate procedure to avoid hemorrhagic complications. Localized means that the tumor has not spread out from where it first started. Learn how we can help 1.2k views Reviewed Dec 09, 2022 Thank 18-13). When fused, the condition is described as crossed fused ectopia. In this case, the right kidney had more favorable anatomy for laparoscopic donor nephrectomy. Each end of the students, the nephron is a massive undertaking, and some masses almost certainly or! Been associated with aortic coarctation, vaginal atresia, and the urethra can! 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